LymphedemaV1, Main, Exploration, bibRecord, 001C80

Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and/or Blue Dye

Identifieur interne : 001C80 ( Main/Exploration ); précédent : 001C79; suivant : 001C81

Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and/or Blue Dye

Auteurs : Alessandro Buda [Italie] ; Cinzia Crivellaro [Italie] ; Federica Elisei [Italie] ; Giampaolo Di Martino [Italie] ; Luca Guerra [Italie] ; Elena De Ponti [Italie] ; Marco Cuzzocrea [Italie] ; Daniela Giuliani [Italie] ; Federica Sina [Italie] ; Sonia Magni [Italie] ; Claudio Landoni [Italie] ; Rodolfo Milani [Italie]

Source :

Annals of Surgical Oncology [ 1068-9265 ] ; 2015.

RBID : PMC:4889617

Abstract

Purpose

To compare the detection rate (DR) and bilateral optimal mapping (OM) of sentinel lymph nodes (SLNs) in women with endometrial and cervical cancer using indocyanine green (ICG) versus the standard technetium-99m radiocolloid (^99mTc) radiotracer plus methylene or isosulfan blue, or blue dye alone.

Methods

From October 2010 to May 2015, 163 women with stage I endometrial or cervical cancer (118 endometrial and 45 cervical cancer) underwent SLN mapping with ^99mTc with blue dye, blue dye alone, or ICG. DR and bilateral OM of ICG were compared respectively with the results obtained using the standard ^99mTc radiotracer with blue dye, or blue dye alone.

Results

SLN mapping with ^99mTc radiotracer with blue dye was performed on 77 of 163 women, 38 with blue dye only and 48 with ICG. The overall DR of SLN mapping was 97, 89, and 100 % for ^99mTc with blue dye, blue dye alone, and ICG, respectively. The bilateral OM rate for ICG was 85 %—significantly higher than the 58 % obtained with ^99mTc with blue dye (p = 0.003) and the 54 % for blue dye (p = 0.001). Thirty-one women (19 %) had positive SLNs. Sensitivity and negative predictive value of SLN were 100 % for all techniques.

Conclusions

SLNs mapping using ICG demonstrated higher DR compared to other modalities. In addition, ICG was significantly superior to ^99mTc with blue dye in terms of bilateral OM in women with early stage endometrial and cervical cancer. The higher number of bilateral OM may consequently reduce the overall number of complete lymphadenectomies, reducing the duration and additional costs of surgical treatment.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889617

DOI: 10.1245/s10434-015-5022-1
PubMed: 26714944
PubMed Central: 4889617

Affiliations:

Italie

Le document en format XML

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<author><name sortKey="Milani, Rodolfo" sort="Milani, Rodolfo" uniqKey="Milani R" first="Rodolfo" last="Milani">Rodolfo Milani</name>
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<series><title level="j">Annals of Surgical Oncology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>To compare the detection rate (DR) and bilateral optimal mapping (OM) of sentinel lymph nodes (SLNs) in women with endometrial and cervical cancer using indocyanine green (ICG) versus the standard technetium-99m radiocolloid (<sup>99m</sup>
Tc) radiotracer plus methylene or isosulfan blue, or blue dye alone.</p>
</sec>
<sec><title>Methods</title>
<p>From October 2010 to May 2015, 163 women with stage I endometrial or cervical cancer (118 endometrial and 45 cervical cancer) underwent SLN mapping with <sup>99m</sup>
Tc with blue dye, blue dye alone, or ICG. DR and bilateral OM of ICG were compared respectively with the results obtained using the standard <sup>99m</sup>
Tc radiotracer with blue dye, or blue dye alone.</p>
</sec>
<sec><title>Results</title>
<p>SLN mapping with <sup>99m</sup>
Tc radiotracer with blue dye was performed on 77 of 163 women, 38 with blue dye only and 48 with ICG. The overall DR of SLN mapping was 97, 89, and 100 % for <sup>99m</sup>
Tc with blue dye, blue dye alone, and ICG, respectively. The bilateral OM rate for ICG was 85 %—significantly higher than the 58 % obtained with <sup>99m</sup>
Tc with blue dye (<italic>p</italic>
 = 0.003) and the 54 % for blue dye (<italic>p</italic>
 = 0.001). Thirty-one women (19 %) had positive SLNs. Sensitivity and negative predictive value of SLN were 100 % for all techniques.</p>
</sec>
<sec><title>Conclusions</title>
<p>SLNs mapping using ICG demonstrated higher DR compared to other modalities. In addition, ICG was significantly superior to <sup>99m</sup>
Tc with blue dye in terms of bilateral OM in women with early stage endometrial and cervical cancer. The higher number of bilateral OM may consequently reduce the overall number of complete lymphadenectomies, reducing the duration and additional costs of surgical treatment.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Buda, Alessandro" sort="Buda, Alessandro" uniqKey="Buda A" first="Alessandro" last="Buda">Alessandro Buda</name>
</noRegion>
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<name sortKey="Crivellaro, Cinzia" sort="Crivellaro, Cinzia" uniqKey="Crivellaro C" first="Cinzia" last="Crivellaro">Cinzia Crivellaro</name>
<name sortKey="Crivellaro, Cinzia" sort="Crivellaro, Cinzia" uniqKey="Crivellaro C" first="Cinzia" last="Crivellaro">Cinzia Crivellaro</name>
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<name sortKey="Di Martino, Giampaolo" sort="Di Martino, Giampaolo" uniqKey="Di Martino G" first="Giampaolo" last="Di Martino">Giampaolo Di Martino</name>
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<name sortKey="Giuliani, Daniela" sort="Giuliani, Daniela" uniqKey="Giuliani D" first="Daniela" last="Giuliani">Daniela Giuliani</name>
<name sortKey="Giuliani, Daniela" sort="Giuliani, Daniela" uniqKey="Giuliani D" first="Daniela" last="Giuliani">Daniela Giuliani</name>
<name sortKey="Guerra, Luca" sort="Guerra, Luca" uniqKey="Guerra L" first="Luca" last="Guerra">Luca Guerra</name>
<name sortKey="Landoni, Claudio" sort="Landoni, Claudio" uniqKey="Landoni C" first="Claudio" last="Landoni">Claudio Landoni</name>
<name sortKey="Landoni, Claudio" sort="Landoni, Claudio" uniqKey="Landoni C" first="Claudio" last="Landoni">Claudio Landoni</name>
<name sortKey="Landoni, Claudio" sort="Landoni, Claudio" uniqKey="Landoni C" first="Claudio" last="Landoni">Claudio Landoni</name>
<name sortKey="Magni, Sonia" sort="Magni, Sonia" uniqKey="Magni S" first="Sonia" last="Magni">Sonia Magni</name>
<name sortKey="Magni, Sonia" sort="Magni, Sonia" uniqKey="Magni S" first="Sonia" last="Magni">Sonia Magni</name>
<name sortKey="Milani, Rodolfo" sort="Milani, Rodolfo" uniqKey="Milani R" first="Rodolfo" last="Milani">Rodolfo Milani</name>
<name sortKey="Milani, Rodolfo" sort="Milani, Rodolfo" uniqKey="Milani R" first="Rodolfo" last="Milani">Rodolfo Milani</name>
<name sortKey="Sina, Federica" sort="Sina, Federica" uniqKey="Sina F" first="Federica" last="Sina">Federica Sina</name>
<name sortKey="Sina, Federica" sort="Sina, Federica" uniqKey="Sina F" first="Federica" last="Sina">Federica Sina</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur le lymphœdème

Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and/or Blue Dye

Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and/or Blue Dye

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